Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
Table 1
Hemodynamic and physiological parameters.
Before ECC
After ECC
− oxygenator
+ oxygenator
− oxygenator
+ oxygenator
Heart rate (bpm)
287 ± 5
292 ± 8
314 ± 11
304 ± 10
MAP (mmHg)
58.3 ± 9.0
60.3 ± 8.3
50.5 ± 8.0
55.1 ± 9.7
Haematocrit (%)
34.5 ± 1.1
33.5 ± 1.8
11.2 ± 6.1
10.2 ± 5.8
Haemoglobin (g/dL)
12.8 ± 0.6
13.0 ± 0.9
4.8 ± 1.2
5.2 ± 0.9
WBC (×103/mm3)
6.2 ± 1.8
5.5 ± 0.7
3.1 ± 0.4
2.7 ± 0.5
SaO2 (%)
98.2 ± 0.5
97.9 ± 0.4
95.2 ± 0.6
96.0 ± 1.1
PaO2 (mmHg)
72.3 ± 5.8
75.0 ± 4.1
69.0 ± 3.0
70.2 ± 9.0
PaCO2 (mmHg)
40.3 ± 5.9
43.0 ± 7.0
39.9 ± 4.0
42.3 ± 6.5
pH
7.32 ± 0.05
7.38 ± 0.04
7.22 ± 0.12
7.14 ± 0.20
BE (mmol/L)
−4.3 ± 1.2
−3.1 ± 1.5
−10.1 ± 4.7
−11.7 ± 6.2
HCO3 (mmol/L)
24.1 ± 7.8
22.0 ± 6.1
11.0 ± 10.1
16.1 ± 9.8
WBC = white blood cells; bpm = beats per minute; MAP = mean arterial pressure; SaO2 = arterial oxygen saturation; PaO2 = partial pressure of arterial oxygen; PaCO2 = partial pressure of arterial carbon dioxide; BE = base excess; HCO3 = standard bicarbonate. Data represent means ± SE.
