Role of Sphingolipids in the Pathobiology of Lung Inflammation

Figure 2

Sphingolipids modulation and bioactivity in cystic fibrosis: prevalent sphingolipids alteration in the alveolar lung compartment and induced responses in endothelial cells (E), alveolar epithelial cells (alveolar type 1 AI, alveolar type 2, AII), macrophages (M), and neutrophils (N). SPT, Serine Palmitoyl Transferase; Cer, ceramide; a SMase, acid Sphingomyelinase; SM, sphingomyelin; lyso-PC, lysophosphatidyl choline; PGE, prostaglandin; S1P, sphingosine-1-phosphate; ROS, reactive oxygen species.