The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors

Figure 4

In vivo granulopoietic response to dexamethasone injection in B6 and Pfp mice ((a), (b)). Data are Mean + SEM of the numbers of EPO+ cells (a) and neutrophils (b) in freshly harvested bone-marrow of age-matched (12 weeks) B6 (white bars) or Pfp (black bars) mice, 24 h after i.p. injection of dexamethasone (Dex, 5 mg/kg) or saline. For B6 and Pfp mice, and , respectively. (c) Data are Mean + SEM of the relative weight of the thymus (mg/g body weight) from age-matched B6 (white bars) or Pfp (black bars) mice, 24 h after injection of dexamethasone or saline as above. For B6 and Pfp mice, and , respectively. Significant differences relative to the indicated controls.

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