Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

Figure 1

Domain architecture schematic for human and mouse CLCA proteins. Each row contains the corresponding human and mouse homologs. Mouse CLCA proteins are labeled according to the recently updated naming commissioned by the Mouse Gene Nomenclature Committee (MGNC) in order to align the numbering established by the Human Gene Nomenclature Committee and the Rat Genome Database. The previously used names for the mouse proteins are shown below the current names and are in italics. Scissors denote the experimentally determined location of proteolytic cleavage sites [18]. Human CLCA3 and mouse CLCA4C are likely pseudogenes because they contain premature stop codons. Labels denote the following domains: CAT: matrix-metalloprotease-like catalytic domain; CYS: matrix-metalloprotease-like cysteine rich domain; vWA: von Willebrand factor type A domain; FnIII: fibronectin type III domain; TM: transmembrane domain; GPI: glycosylphosphatidylinositol anchor.