Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

Figure 3

Domain architecture schematic for human TMEM16A. Topology shown is predicted from structure-based alignment to the crystal structure of the fungal Nectria haematococca TMEM16 [31]. Alternative splicing segments , , , and are shown in magenta. The location of residues of a crystallographically determined Ca²⁺ binding site is highlighted with stars. The extracellular loop mediating interaction with CLCA1 is highlighted in green.