Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway

Figure 2

Calcitriol potentiates anti-HCV effect of miR-130a in both Con1b replicon (a) and J6/JFH1 culture systems (b). Huh7.5-Con1b replicon cells (a) or J6/JFH1 infected HCVcc (b) were transfected with 2 nM miR-130a mimic or treated with 0.1 μM calcitriol or both and HCV RNAs were quantified by quantitative RT-PCR 48 h after transfection as described in Section 2. Data are presented as , . ; versus control and mock and Nc (microRNA mimic negative control).

(a)

(b)