Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis

Table 3

Factors associated with MS and DCs.

	Immunological effect	Effect on MS/EAE
Vitamin D	Induces Tregs and tolerogenic DCs	Reduces relapses of MS and changes clinical parameters of MS
Estrogen	Inhibits Th1 and Th2 cytokines secretion; induces tolerogenic DCs	Relieves symptoms of MS and reduces incidence of MS