Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

Figure 1

Cocaine intake causes severe liver injury and malfunction. (a) Liver confocal intravital microscopy showing that while control mice have a well perfused liver vasculature (evidenced by PE-anti-CD31 antibody staining, in red) and absence of necrosis (in green), cocaine-treated mice had several dark areas in the red channel, which are suggestive of malperfusion caused by necrosis (elicited by DNA staining using Sytox Green). (b) Serum liver transaminase levels and (c) retention of cardiogreen confirmed necrosis. Statistical significance in comparison to controls (). A 10x objective was used during imaging. One-way ANOVA with Tukey’s post hoc test. Data are expressed as . ( mice/treatment).

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