Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
High doses of cocaine promote acute behavioral seizure. (a) Representative picture of seizure characterized by rapid myoclonic convulsions of forelimbs and tail clonus preceded by locomotor depression. (b) Acute overdose induced seizure in all animals represented by latency reduced and duration increased compared to group vehicle. (c) Positive correlation between seizure duration and acute hepatotoxicity induced by cocaine (, for ALT; , for cardiogreen). Significantly different from vehicle group (). One-way ANOVA with Tukey’s post hoc test. Data are expressed as mean S.E.M ( mice/treatment).
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