Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

Figure 4

Acetaminophen model of acute liver injury and failure. (a) Liver confocal intravital microscopy showing that while control mice have a well perfused liver vasculature (evidenced by PE-anti-CD31 antibody staining, in red) and absence of necrosis (in green), APAP-treated mice (600 mg/Kg) had several dark areas in the red channel, which are suggestive of malperfusion caused by necrosis (elicited by DNA staining using Sytox Green). (b) Serum liver transaminase levels confirmed necrosis. Statistical significance in comparison to controls (). A 10x objective was used during imaging. One-way ANOVA with Tukey’s post hoc test. Data are expressed as ( mice/treatment).

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