Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

Figure 6

Previous hepatic injury (24 hours) with APAP interferes in seizure dynamics. (a) Administration of APAP at doses of 600 and 800 mg/kg 24 hours before cocaine administration increased lethality when compared to group vehicle/cocaine. (b) APAP at dose of 800 mg/kg reduced percentage of seizures and its duration (c). (d) Previous administration of APAP at dose of 600 mg/kg decreased seizure latency. APAP at dose of 800 mg/kg enhanced seizure latency. Significantly different from vehicle group (). Significantly different from vehicle group (). Significantly different from vehicle group (). One-way ANOVA with Tukey’s post hoc test. Data are expressed as ( mice/treatment).

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