Soluble ST2 Plasma Concentrations Predict Mortality in HBV-Related Acute-on-Chronic Liver Failure

Table 1

Baseline characteristics of patients with hepatitis B-related acute-on-chronic liver failure (HBV-ACLF), patients with chronic hepatitis B, and healthy controls.

Characteristics	HBV-ACLF; ( = 48)	Chronic hepatitis B; ( = 12)	Healthy controls; ( = 16)	Statistic	value
Sex, male : female	45 : 3	11 : 1	12 : 4	= 4.55	0.12
Age, years	38.38 ± 9.47	34.00 ± 7.80	36.38 ± 13.55	= 0.95	0.39
ALT, U/L; (median, IQR)	404.00; (139.75–815.25)	179.5; (70.75–246.00)	17.5; (16–22)	= 42.51	<0.001
TBIL, μmol/L (mean ± SD)	367.56 ± 190.58	23.26 ± 13.27	11.78 ± 3.5	= 46.51	<0.001
INR; (median, IQR)	1.89; (1.63–2.56)	0.98; (0.86–1.04)	0.93; (0.85–1.02)	= 52.41	<0.001
HBV DNA,  IU/mL, (mean ± SD)	5.96 ± 1.95	6.58 ± 1.26	NA	= −1.05	0.29

ALT, alanine aminotransferase; INR, prothrombin time international normalized ratio; IQR, 25%–75% interquartile range; NA, not applicable; TBIL, total bilirubin. -values for differences between three groups were determined with Student’s -test for parameter data and Kruskal-Wallis test for nonparametric data.