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Mediators of Inflammation
Volume 2015 (2015), Article ID 539841, 9 pages
http://dx.doi.org/10.1155/2015/539841
Research Article

Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression

1Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui-Jin Er Road, Shanghai 200025, China
2Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui-Jin Er Road, Shanghai 200025, China

Received 10 February 2015; Revised 13 April 2015; Accepted 14 April 2015

Academic Editor: Stefanie B. Flohé

Copyright © 2015 Tingting Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Cheng, G. Xie, S. Yao et al., “Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China,” Critical Care Medicine, vol. 35, no. 11, pp. 2538–2546, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. S. Hotchkiss, G. Monneret, and D. Payen, “Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach,” The Lancet Infectious Diseases, vol. 13, no. 3, pp. 260–268, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. S. Boomer, K. To, K. C. Chang et al., “Immunosuppression in patients who die of sepsis and multiple organ failure,” The Journal of the American Medical Association, vol. 306, no. 23, pp. 2594–2605, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. F.-Y. Leng, J.-L. Liu, Z.-J. Liu, J.-Y. Yin, and H.-P. Qu, “Increased proportion of CD4+CD25+Foxp3+ regulatory T cells during early-stage sepsis in ICU patients,” Journal of Microbiology, Immunology and Infection, vol. 46, no. 5, pp. 338–344, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. X. Yuan, G. Cheng, and T. R. Malek, “The importance of regulatory T-cell heterogeneity in maintaining self-tolerance,” Immunological Reviews, vol. 259, no. 1, pp. 103–114, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. Y.-S. Zheng, Z.-S. Wu, H.-B. Ni et al., “Codonopsis pilosula polysaccharide attenuates cecal ligation and puncture sepsis via circuiting regulatory T cells in mice,” Shock, vol. 41, no. 3, pp. 250–255, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Huang, F. Venet, Y. L. Wang et al., “PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 15, pp. 6303–6308, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Keir, M. J. Butte, G. J. Freeman, and A. H. Sharpe, “PD-1 and its ligands in tolerance and immunity,” Annual Review of Immunology, vol. 26, pp. 677–704, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. J. Butte, M. E. Keir, T. B. Phamduy, A. H. Sharpe, and G. J. Freeman, “Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses,” Immunity, vol. 27, no. 1, pp. 111–122, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Blank and A. Mackensen, “Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion,” Cancer Immunology, Immunotherapy, vol. 56, no. 5, pp. 739–745, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Zhang, J. Li, J. Lou et al., “Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients,” Critical Care, vol. 15, no. 1, article R70, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Shindo, J. Unsinger, C. A. Burnham, J. M. Green, and R. S. Hotchkiss, “Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression,” Shock, vol. 43, no. 4, pp. 334–343, 2015. View at Publisher · View at Google Scholar
  13. G. F. Hoyne, M. J. Dallman, B. R. Champion, and J. R. Lamb, “Notch signalling in the regulation of peripheral immunity,” Immunological Reviews, vol. 182, no. 1, pp. 215–227, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. R. C. Bone, “Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome),” The Journal of the American Medical Association, vol. 268, no. 24, pp. 3452–3455, 1992. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Tsuchiya, Y. Kobayashi, Y. Goto et al., “Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester,” Cancer Research, vol. 42, no. 4, pp. 1530–1536, 1982. View at Google Scholar · View at Scopus
  16. K. E. A. LaRue and C. E. McCall, “A labile transcriptional repressor modulates endotoxin tolerance,” Journal of Experimental Medicine, vol. 180, no. 6, pp. 2269–2275, 1994. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Zhang, Y. Zhou, J. Lou et al., “PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction,” Critical Care, vol. 14, no. 6, p. R220, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. S. F. Monaghan, R. K. Thakkar, M. L. Tran et al., “Programmed death 1 expression as a marker for immune and physiological dysfunction in the critically Ill surgical patient,” Shock, vol. 38, no. 2, pp. 117–122, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Brahmamdam, S. Inoue, J. Unsinger, K. C. Chang, J. E. McDunn, and R. S. Hotchkiss, “Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis,” Journal of Leukocyte Biology, vol. 88, no. 2, pp. 233–240, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Mathieu, N. Cotta-Grand, J.-F. Daudelin, P. Thébault, and N. Labrecque, “Notch signaling regulates PD-1 expression during CD8+ T-cell activation,” Immunology and Cell Biology, vol. 91, no. 1, pp. 82–88, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. K. G. Guruharsha, M. W. Kankel, and S. Artavanis-Tsakonas, “The Notch signalling system: recent insights into the complexity of a conserved pathway,” Nature Reviews Genetics, vol. 13, no. 9, pp. 654–666, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Kopan and M. X. G. Ilagan, “The canonical Notch signaling pathway: unfolding the activation mechanism,” Cell, vol. 137, no. 2, pp. 216–233, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. G. F. Hoyne, M. J. Dallman, and J. R. Lamb, “T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling,” Immunology, vol. 100, no. 3, pp. 281–288, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Ostroukhova, Z. Qi, T. B. Oriss, B. Dixon-McCarthy, P. Ray, and A. Ray, “Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β,” Journal of Clinical Investigation, vol. 116, no. 4, pp. 996–1004, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. P. N. Tsao, S. C. Wei, M. T. Huang et al., “Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response,” Journal of Biomedical Science, vol. 18, article 56, 2011. View at Publisher · View at Google Scholar
  26. A. Huang, B. Zhang, W. Yan et al., “Myeloid-derived suppressor cells regulate immune response in patients with chronic hepatitis B virus infection through PD-1-induced IL-10,” The Journal of Immunology, vol. 193, no. 11, pp. 5461–5469, 2014. View at Publisher · View at Google Scholar
  27. M. B. Ka, F. Gondois-Rey, C. Capo et al., “Imbalance of circulating monocyte subsets and PD-1 dysregulation in Q fever endocarditis: the role of IL-10 in PD-1 modulation,” PLoS ONE, vol. 9, no. 9, Article ID e107533, 2014. View at Publisher · View at Google Scholar
  28. H. M. Huang, G. Hsiao, C. K. Fan et al., “Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production,” PLoS ONE, vol. 8, no. 5, Article ID e63613, 2013. View at Publisher · View at Google Scholar · View at Scopus