Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

Figure 3

Pharmacological inhibition of PI3Kγ decreases neutrophilic airway inflammation in βENaC-Tg mice. Neutrophils (a), lymphocytes (b), and macrophages (c) numbers were determined in BAL fluid of control (WT/Vehicle) and βENaC-Tg mice untreated or treated with the PI3Kγ inhibitor AS-605240 (βENaC-Tg/AS-605240) or with vehicle (βENaC-Tg/Vehicle). Cells are expressed as number per mL of BAL fluid. (a) WT/Vehicle versus βENaC-Tg/Vehicle, βENaC-Tg/Vehicle versus βENaC-Tg/AS-605240 and WT/Vehicle versus /βENaC-Tg. (b) WT/Vehicle versus βENaC-Tg/Vehicle and WT/Vehicle versus /βENaC-Tg. (c). WT/Vehicle versus βENaC-Tg/Vehicle, WT/Vehicle versus βENaC-Tg/AS-605240, and WT/Vehicle versus /βENaC-Tg.

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