Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

Table 1

Frequency of articles published between January 1, 1996, and December 31, 2013, that were selected for the systematic review regarding dental infections, leprosy reactions, and the types of investigated inflammatory mediators.

Inflammatory mediators	Type of article
	Dental infections		Leprosy reactions
		%		%
IL-1β	29	42.7	3	30.0
TNF-α	25	36.8	7	70.0
IL-6	24	35.3	4	40.0
IFN-γ	17	25.0	5	50.0
IL-4	15	22.0	4	40.0
IL-10	13	19.1	4	40.0
IL-17	13	19.1	3	30.0
IL-8	12	17.6	2	20.0
IL-2	11	16.2	1	10.0
IL-12	6	8.8	2	20.0
IL-1α	6	8.8
IL-18	5	7.3
IL-23	4	5.9
IL-5	4	5.9	2	20.0
IL-11	4	5.9
TGF-1β	4	5.9	1	10.0
IL-13	4	5.9	1	10.0
IL-15	3	4.4	1	10.0
IL-7	2	2.9	1	10.0
IL-12p40	2	2.9
IL-12p70	2	2.9
IL-23p19	2	2.9
IL-9	1	1.5	1	11.1
IL-12p35	1	1.5
IL-21	1	1.5

Number of articles about dental infections.
Number of articles about leprosy reactions.
Included in the cytokines IL-17A and IL-17F.