Review Article

Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored

Table 1

Biomarkers in GBS.

Classification of biomarkersBiomarkers

Infection-associated biomarkersLOS, serotype and sequence type of Campylobacter jejuni DNA-binding protein
Immune-associated biomarkers
 Gene polymorphismsFcR, HLA, CD1, CD95, TNF-α, mannose-binding lectin, macrophage mediators, TCR, TLR4, killer-immunoglobulin-like receptor, glucocorticoid receptor
 CytokinesIFN-γ, TNF-α, IL-17, IL-22, IL-18, IL-1β, IL-10, IL-6, IL-12, IL-16, IL-23, IL-37, TGF-β1
 ComplementsC3, C5b-9, C5a
 Chemokines CCL2, CCL3, CX3CL1, CXCL2, CXCL10, CCL7, CCL27, CXCL9, CXCL12
 OthersErythropoietin, heat shock protein, apolipoprotein E, C-reactive protein, neopterin, matrix metalloproteinases, reactive oxygen species, cell adhesion molecules, microRNA-155, osteopontin
BNB/B-CSF-B damage-associated biomarkers
 Brain-derived proteinsTotal protein, prealbumin, transthyretin, S100B, cystatin C, prostaglandin D(2) synthase, hypocretin-1
 Blood-derived proteinsHaptoglobin, fibrinogen, Apo A-IV, ApoH, vitamin D-binding protein, α-1-antitrypsin
PNS damage-associated biomarkers
 Myelin sheath-associated biomarkersAutoantibodies to ganglioside, neurofascin, gliomedin, P0, PMP22, , connexin 32, α6β4, phospholipid
 Neuron-component-associated biomarkersNeurofilaments, tau proteins, 14-3-3 proteins, neuron-specific enolase
Other biomarkers for GBSCreatine kinase heparin sulfate glycosaminoglycans, glial fibrillary acid protein, triglyceride and hyponatremia