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Mediators of Inflammation
Volume 2015, Article ID 569714, 7 pages
Research Article

An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes

1Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca MútuaTerrassa, Mutua de Terrassa Hospital, Sant Antoni 19, Terrassa, 08221 Barcelona, Spain
2Neurology Department, Mutua de Terrassa Hospital, Terrassa, 08221 Barcelona, Spain
3Neurovascular Research Laboratory, Vall d’Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona, Spain

Received 19 January 2015; Revised 13 July 2015; Accepted 15 July 2015

Academic Editor: Dianne Cooper

Copyright © 2015 Elena Muiño et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Inflammation has been associated with atherothrombotic stroke and recently with cardioembolic stroke. Different genetic risk factors have been specifically associated with the subtypes of ischemic stroke (cardioembolic, atherothrombotic, and lacunar). However, there are no studies that have generated genetic risk scores for the different subtypes of ischemic stroke using polymorphisms associated with inflammation. Methods. We have analyzed 68 polymorphisms of 30 inflammatory mediator genes in 2,685 subjects: 1,987 stroke cases and 698 controls. We generated a genetic scoring system with the most significant polymorphisms weighted by the odds ratio of every polymorphism and taken into consideration the stroke subtype. Results. Three polymorphisms, rs1205 (CRP gene), rs1800779, and rs2257073 (NOS3 gene), were associated with cardioembolic stroke ( value ). The score generated was only associated with the cardioembolic stroke subtype ( value: 0.001) and was replicated in an independent cohort ( value: 0.017). The subjects with the highest score presented a cardioembolic stroke in 92.2% of the cases ( value: 0.002). Conclusion. The genetics of inflammatory markers is more closely associated with cardioembolic strokes than with atherothrombotic or lacunar strokes. The genetic risk scoring system could be useful in the prediction and differentiation of ischemic stroke; however, it might be specific to particular ischemic stroke subtypes.