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Mediators of Inflammation
Volume 2015, Article ID 587378, 11 pages
http://dx.doi.org/10.1155/2015/587378
Research Article

The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture

1Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China
2Department of Orthopaedics, Beijing Army General Hospital, Beijing 100700, China
3Department of Respiratory Diseases, Chronic Airways Diseases Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China

Received 12 December 2014; Revised 8 February 2015; Accepted 20 February 2015

Academic Editor: Chung-Hsi Hsing

Copyright © 2015 Li Gan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. J. W. Roche, R. T. Wenn, O. Sahota, and C. G. Moran, “Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study,” British Medical Journal, vol. 331, no. 7529, pp. 1374–1376, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. C. B. Wang, C. F. J. Lin, W. M. Liang et al., “Excess mortality after hip fracture among the elderly in Taiwan: a nationwide population-based cohort study,” Bone, vol. 56, no. 1, pp. 147–153, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Alzahrani, R. Gandhi, A. Davis, and N. Mahomed, “In-hospital mortality following hip fracture care in southern Ontario,” Canadian Journal of Surgery, vol. 53, no. 5, pp. 294–298, 2010. View at Google Scholar · View at Scopus
  4. P. Vestergaard, L. Rejnmark, and L. Mosekilde, “Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications,” Osteoporosis International, vol. 18, no. 12, pp. 1583–1593, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Haleem, L. Lutchman, R. Mayahi, J. E. Grice, and M. J. Parker, “Mortality following hip fracture: trends and geographical variations over the last 40 years,” Injury, vol. 39, no. 10, pp. 1157–1163, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Simunovic, P. J. Devereaux, S. Sprague et al., “Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis,” Canadian Medical Association Journal, vol. 182, no. 15, pp. 1609–1616, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. C. E. Uzoigwe, H. G. F. Burnand, C. L. Cheesman, D. O. Aghedo, M. Faizi, and R. G. Middleton, “Early and ultra-early surgery in hip fracture patients improves survival,” Injury, vol. 44, no. 6, pp. 726–729, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. C. L. Daugaard, H. L. Jorgensen, T. Riis, J. B. Lauritzen, B. R. Duus, and S. Van Der Mark, “Is mortality after hip fracture associated with surgical delay or admission during weekends and public holidays? A retrospective study of 38,020 patients,” Acta Orthopaedica, vol. 83, no. 6, pp. 609–613, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Sun, X. Wang, Z. Liu, S. Liu, and J. Zhang, “Patterns of cytokine release and evolution of remote organs from proximal femur fracture in COPD rats,” Injury, vol. 42, no. 8, pp. 825–832, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Sun, X. Wang, Z. Liu, X. Chen, and J. Zhang, “Plasma concentrations of pro- and anti-inflammatory cytokines and outcome prediction in elderly hip fracture patients,” Injury, vol. 42, no. 7, pp. 707–713, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Zhang, T. Sun, Z. Liu, J. Zhang, X. Wang, and J. Liu, “Systemic inflammatory responses and lung injury following hip fracture surgery increases susceptibility to infection in aged rats,” Mediators of Inflammation, vol. 2013, Article ID 536435, 12 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. P. F. Stahel, W. R. Smith, and E. E. Moore, “Current trends in resuscitation strategy for the multiply injured patient,” Injury, vol. 40, supplement 4, pp. S27–S35, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Hildebrand, P. Giannoudis, C. Kretteck, and H.-C. Pape, “Damage control: extremities,” Injury, vol. 35, no. 7, pp. 678–689, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Sagan, “On the origin of mitosing cells,” Journal of Theoretical Biology, vol. 14, no. 3, pp. 225–274, 1967. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Pugin, “How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome,” Annals of Intensive Care, vol. 2, article, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. V. M. Stoecklein, A. Osuka, and J. A. Lederer, “Trauma equals danger-damage control by the immune system,” Journal of Leukocyte Biology, vol. 92, no. 3, pp. 539–551, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Gu, Y. Yao, G. Wu, T. Lv, L. Luo, and Y. Song, “The plasma mitochondrial dna is an independent predictor for post-traumatic systemic inflammatory response syndrome,” PLoS ONE, vol. 8, no. 8, Article ID e72834, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. C. J. Hauser, T. Sursal, E. K. Rodriguez, P. T. Appleton, Q. Zhang, and K. Itagaki, “Mitochondrial damage associated molecular patterns from femoral reamings activate neutrophils through formyl peptide receptors and P44/42 MAP kinase,” Journal of Orthopaedic Trauma, vol. 24, no. 9, pp. 534–538, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Q. Zhang, K. Itagaki, and C. J. Hauser, “Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase,” Shock, vol. 34, no. 1, pp. 55–59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Q. Zhang, M. Raoof, Y. Chen et al., “Circulating mitochondrial DAMPs cause inflammatory responses to injury,” Nature, vol. 464, no. 7285, pp. 104–107, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. J.-Z. Zhang, Z. Liu, J. Liu, J.-X. Ren, and T.-S. Sun, “Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue,” International Journal of Molecular Medicine, vol. 33, no. 4, pp. 817–824, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. H.-J. He, Y. Wang, Y. Le et al., “Surgery up regulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats,,” CNS Neuroscience and Therapeutics, vol. 18, no. 12, pp. 994–1002, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. B. W. Sears, D. Volkmer, S. Yong et al., “Binge alcohol exposure modulates rodent expression of biomarkers of the immunoinflammatory response to orthopaedic trauma,” The Journal of Bone and Joint Surgery—American Volume, vol. 93, no. 8, pp. 739–749, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Deree, J. Martins, T. de Campos et al., “Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock,” Journal of Surgical Research, vol. 143, no. 1, pp. 99–108, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Ellinger, D. C. Müller, S. C. Müller et al., “Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignancies,” Urologic Oncology, vol. 30, no. 4, pp. 509–515, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Hirsiger, H.-P. Simmen, C. M. L. Werner, G. A. Wanner, and D. Rittirsch, “Danger signals activating the immune response after trauma,” Mediators of Inflammation, vol. 2012, Article ID 315941, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Keel and O. Trentz, “Pathophysiology of polytrauma,” Injury, vol. 36, no. 6, pp. 691–709, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. P.-B. Xu, J.-S. Lou, Y. Ren, C.-H. Miao, and X.-M. Deng, “Gene expression profiling reveals the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome,” Journal of Infection, vol. 65, no. 5, pp. 380–391, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Visser, J. Pillay, L. Koenderman, and L. P. H. Leenen, “Post-injury immune monitoring: can multiple organ failure be predicted?” Current Opinion in Critical Care, vol. 14, no. 6, pp. 666–672, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. J. Hoth, J. D. Wells, S. E. Jones, B. K. Yoza, and C. E. McCall, “Complement mediates a primed inflammatory response after traumatic lung injury,” Journal of Trauma and Acute Care Surgery, vol. 76, no. 3, pp. 601–609, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. S. F. Monaghan, R. K. Thakkar, D. S. Heffernan et al., “Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1,” Annals of Surgery, vol. 255, no. 1, pp. 158–164, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Tiansheng, C. Xiaobin, L. Zhi, W. Xiaowei, L. Guang, and Z. Liren, “Is damage control orthopedics essential for the management of bilateral femoral fractures associated or complicated with shock? an animal study,” Journal of Trauma—Injury, Infection and Critical Care, vol. 67, no. 6, pp. 1402–1411, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Forasassi, J.-L. Golmard, E. Pautas, F. Piette, I. Myara, and A. Raynaud-Simon, “Inflammation and disability as risk factors for mortality in elderly acute care patients,” Archives of Gerontology and Geriatrics, vol. 48, no. 3, pp. 406–410, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. R. M. Smith, “Immunity, trauma and the elderly,” Injury, vol. 38, no. 12, pp. 1401–1404, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. Q. Zhu, X. Qian, S. Wang et al., “A comparison of elderly and adult multiple organ dysfunction syndrome in the rat model,” Experimental Gerontology, vol. 41, no. 8, pp. 771–777, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Tornetta III, H. Mostafavi, J. Riina et al., “Morbidity and mortality in elderly trauma patients,” Journal of Trauma—Injury, Infection and Critical Care, vol. 46, no. 4, pp. 702–706, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. S. M. Henry, A. N. Pollak, A. L. Jones, S. Boswell, and T. M. Scalea, “Pelvic fracture in geriatric patients: a distinct clinical entity,” Journal of Trauma, vol. 53, no. 1, pp. 15–20, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. C. S. Roberts, H.-C. Pape, A. L. Jones, A. L. Malkani, J. L. Rodriguez, and P. V. Giannoudis, “Damage control orthopaedics: evolving concepts in the treatment of patients who have sustained orthopaedic trauma,” Instructional course lectures, vol. 54, pp. 447–462, 2005. View at Google Scholar · View at Scopus
  39. L. Moja, A. Piatti, V. Pecoraro et al., “Timing matters in hip fracture surgery: patients operated within 48 hours have better outcomes. A meta-analysis and meta-regression of over 190,000 patients,” PLoS ONE, vol. 7, no. 10, Article ID e46175, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. E. I. O. Vidal, D. C. Moreira-Filho, R. S. Pinheiro et al., “Delay from fracture to hospital admission: a new risk factor for hip fracture mortality?” Osteoporosis International, vol. 23, no. 12, pp. 2847–2853, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. A. J. Rogers and M. A. Matthay, “Applying metabolomics to uncover novel biology in ARDS,” The American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 306, no. 11, pp. L957–L961, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Bhargava and C. H. Wendt, “Biomarkers in acute lung injury,” Translational Research, vol. 159, no. 4, pp. 205–217, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. L. J. M. Cross and M. A. Matthay, “Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury,” Critical Care Clinics, vol. 27, no. 2, pp. 355–377, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. R. D. Fremont, T. Koyama, C. S. Calfee et al., “Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis,” Journal of Trauma—Injury, Infection and Critical Care, vol. 68, no. 5, pp. 1121–1127, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Pugin, “Biomarkers of sepsis: is procalcitonin ready for prime time?” Intensive Care Medicine, vol. 28, no. 9, pp. 1203–1204, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. E. B. Yan, L. Satgunaseelan, E. Paul et al., “Post-traumatic hypoxia is associated with prolonged cerebral cytokine production, higher serum biomarker levels, and poor outcome in patients with severe traumatic brain injury,” Journal of Neurotrauma, vol. 31, no. 7, pp. 618–629, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. V. Ciriello, S. Gudipati, P. Z. Stavrou, N. K. Kanakaris, M. C. Bellamy, and P. V. Giannoudis, “Biomarkers predicting sepsis in polytrauma patients: current evidence,” Injury, vol. 44, no. 12, pp. 1680–1692, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. L. V. Collins, S. Hajizadeh, E. Holme, I.-M. Jonsson, and A. Tarkowski, “Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses,” Journal of Leukocyte Biology, vol. 75, no. 6, pp. 995–1000, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. S.-Y. Seong and P. Matzinger, “Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses,” Nature Reviews Immunology, vol. 4, no. 6, pp. 469–478, 2004. View at Publisher · View at Google Scholar · View at Scopus