Human Leucocyte Antigen-G (HLA-G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection
Table 1
Genotype and allele frequencies of variation sites at HLA-G 3′ untranslated region (3′UTR) in patients with Chagas disease stratified according to clinical forms and healthy individuals.
3′UTR variation sites
Clinical forms
I
C
D
M
CDM
W
H
Freq.
Freq.
Freq.
Freq.
Freq.
Freq.
Freq.
14 bp I/D
(n = 39)
(n = 52)
(n = 62)
(n = 24)
(n = 138)
(n = 177)
(n = 155)
II
8
0.2051
14
0.2692
8
0.1290
5
0.2083
27
0.1957
35
0.1977
30
0.1935
DI
19
0.4872
20
0.3846
32
0.5161
12
0.5000
64
0.4638
83
0.4689
67
0.4323
DD
12
0.3077
18
0.3462
22
0.3548
7
0.2917
47
0.3406
59
0.3333
58
0.3742
I allele
35
0.4487
48
0.4615
48
0.3871
22
0.4583
118
0.4275
153
0.4322
127
0.4097
D allele
43
0.5513
56
0.5385
76
0.6129
26
0.5417
158
0.5725
201
0.5678
183
0.5903
+3001C/T
(n = 39)
(n = 52)
(n = 62)
(n = 24)
(n = 138)
(n = 177)
(n = 155)
CC
39
1.0000
52
1.0000
61
0.9839
24
1.0000
137
0.9928
176
0.9944
155
1.0000
CT
0
0.0000
0
0.0000
1
0.0161
0
0.0000
1
0.0072
1
0.0056
0
0.0000
TT
0
0.0000
0
0.0000
0
0.0000
0
0.0000
0
0.0000
0
0,0000
0
0.0000
C allele
78
1.0000
104
1.0000
123
0.9919
48
1.0000
275
0.9964
353
0.9972
310
1.0000
T allele
0
0.0000
0
0.0000
1
0.0081
0
0.0000
1
0.0036
1
0.0028
0
0.0000
+3003T/C
(n = 39)
(n = 52)
(n = 62)
(n = 24)
(n = 138)
(n = 177)
(n = 155)
TT
32
0.8205
45
0.8654
54
0.8710*
20
0.8333
119
0.8623*
151
0.8531*
114
0.7354*
CT
7
0.1795
7
0.1346
8
0.1290*
4
0.1667
19
0.1377*
26
0.1469*
40
0.2581*
CC
0
0.0000
0
0.0000
0
0.0000
0
0.0000
0
0.0000
0
0.0000
1
0.0065
T allele
71
0.9103
97
0.9327
116
0.9355*
44
0.9167
257
0.9312*
328
0.9266*
268
0.8645*
C allele
7
0.0897
7
0.0673
8
0.0645*
4
0.0833
19
0.0688*
26
0.0734*
42
0.1355*
+3010C/G
(n = 39)
(n = 52)
(n = 62)
(n = 24)
(n = 138)
(n = 177)
(n = 155)
CC
15
0.3846
21
0.4038
16
0.2581
10
0.4167
47
0.3406
62
0.3503
44
0.2839
GC
14
0.3590
16
0.3077*
31
0.5000
9
0.3750
56
0.4058
70
0.3955*
74
0.4774*
GG
10
0.2564
15
0.2885
15
0.2419
5
0.2083
35
0.2536
45
0.2542
37
0.2387
C allele
44
0.5641
58
0.5577
63
0.5081
29
0.6042
150
0.5435
194
0.5480
162
0.5226
G allele
34
0.4359
46
0.4423
61
0.4919
19
0.3958
126
0.4565
160
0.4520
148
0.4774
+3027A/C
(n = 39)
(n = 52)
(n = 62)
(n = 24)
(n = 138)
(n = 177)
(n = 155)
AA
0
0.0000
0
0.0000
0
0.0000
0
0.0000
0
0.0000
0
0.0000
1
0.0065
AC
6
0.1538*
6
0.1154*
0
0.0000*
4
0.1667*
10
0.0725
16
0.0904
15
0.0968*
CC
33
0.8462
46
0.8846
62
1.0000
20
0.8333
128
0.9275
161
0.9096
139
0.8967*
A allele
6
0.0769*
6
0.0577*
0
0.0000*
4
0.0833*
10
0.0362
16
0.0452
17
0.0548*
C allele
72
0.9231*
98
0.9423*
124
1.0000*
44
0.9167*
266
0.9638
338
0.9548
293
0.9452*
+3035C/T
(n = 39)
(n = 52)
(n = 62)
(n = 24)
(n = 138)
(n = 177)
(n = 155)
CC
30
0.7692
38
0.7308*
56
0.9032*
17
0.7083*
111
0.8043
141
0.7966
111
0.7161*
CT
7
0.1795
12
0.2308
6
0.0968*
7
0.2917*
25
0.1812
32
0.1808
40
0.2581*
TT
2
0.0513
2
0.0384
0
0.0000
0
0.0000
2
0.0145
4
0.0226
4
0.0258
C allele
67
0.8590*
88
0.8462*
118
0.9516*
41
0.8542*
247
0.8949
314
0.8870
262
0.8452*
T allele
11
0.1410*
16
0.1538*
6
0.0484*
7
0.1458*
29
0.1051
40
0.1130
48
0.1548*
+3142G/C
(n = 39)
(n = 51)
(n = 60)
(n = 24)
(n = 135)
(n = 174)
(n = 155)
GG
16
0.4103*
21
0.4118*
13
0.2166*
11
0.4583*
45
0.3333
61
0.3505
44
0.2839
GC
15
0.3846
15
0.2941*
31
0.5167*
8
0.3333
54
0.4000
69
0.3966*
80
0.5161*
CC
8
0.2051
15
0.2941
16
0.2667
5
0.2084
36
0.2667
44
0.2529
31
0.2000
G allele
47
0.6026
57
0.5588
57
0.4750
30
0.6250
144
0.5333
191
0.5489
168
0.5419
C allele
31
0.3974
45
0.4412
63
0.5250
18
0.3750
126
0.4667
157
0.4511
142
0.4581
+3187A/G
(n = 39)
(n = 50)
(n = 61)
(n = 24)
(n = 135)
(n = 174)
(n = 155)
AA
22
0.5641
27
0.5400
26
0.4262
14
0.5833
67
0.4963
89
0.5115
82
0.5290
GA
12
0.3077
16
0.3200
29
0.4754
7
0.2917
52
0.3852
64
0.3678
66
0.4258
GG
5
0.1282
7
0.1400*
6
0.0984
3
0.1250
16
0.1185*
21
0.1207*
7
0.0452*
A allele
56
0.7179
70
0.7000
81
0.6639
35
0.7292
186
0.6889
242
0.6954
230
0.7419
G allele
22
0.2821
30
0.3000
41
0.3361
13
0.2708
84
0.3111
106
0.3046
80
0.2581
+3196C/G
(n = 39)
(n = 50)
(n = 61)
(n = 24)
(n = 135)
(n = 174)
(n = 155)
CC
22
0.5641
24
0.4800
25
0.4098
8
0.3333*
57
0.4222*
79
0.4540
86
0.5548*
GC
12
0.3077*
22
0.4400
31
0.5082
15
0.6250*
68
0.5037*
80
0.4598
58
0.3742*
GG
5
0.1282
4
0.0800
5
0.0820
1
0.0417
10
0.0741
15
0.0862
11
0.0710
C allele
56
0.7179
70
0.7000
81
0.6639
31
0.6458
182
0.6741
238
0.6839
230
0.7419
G allele
22
0.2821
30
0.3000
41
0.3361
17
0.3542
88
0.3259
110
0.3161
80
0.2581
I (indeterminate). C (cardiac). D (digestive). M (mixed). CDM (patients presenting clinically detected disease). W (whole group). H (healthy control). *frequencies that show statistical differences.
