Human Leucocyte Antigen-G (HLA-G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection

Table 3

(a) Haplotype frequencies in patients with Chagas disease stratified according to clinical forms and healthy controls and (b) Odds Ratio and 95% Confidence Interval values obtained from the comparisons of haplotypes frequencies of variation sites at HLA-G 3′ untranslated region (3′UTR) between different presentation forms of Chagas disease and healthy controls.

(a)

Haplotype		Clinical forms
		I		C		D		M		CDM		W		H
		n	Freq.	n	Freq.	n	Freq.	n	Freq.	n	Freq.	n	Freq.	n	Freq.
UTR-1	DelCTGCCCGC	17	0.25	27	0.28	40	0.32	80	0.26	80	0.30	80	0.26	80	0.26
UTR-2	InsCTCCCGAG	20	0.29	28	0.29	37	0.31	75	0.24	80	0.30	75	0.24	75	0.24
UTR-3	DelCTCCCGAC	11	0.16	12	0.12	13	0.11	39	0.13	32	0.12	39	0.13	39	0.13
UTR-4	DelCCGCCCAC	4	0.06	3	0.03^*	7	0.06^*	41	0.13	13	0.05^*	41	0.13^*	41	0.13^*
UTR-5	InsCTCCTGAC	3	0.04	11	0.11	5	0.04	29	0.09	18	0.07	29	0.09	29	0.09
UTR-6	DelCTGCCCAC	3	0.04	6	0.06	11	0.09	21	0.07	19	0.07	21	0.07	21	0.07
UTR-7	InsCTCATGAC	5	0.07^*	3	0.03	0	0.00^*	17	0.05^*	7	0.03	17	0.05	17	0.05^*
UTR-8	InsCTGCCGAG	1	0.02	0	0.00	0	0.00	4	0.01	0	0.00	4	0.01	4	0.01
UTR-10	DelCTCCCGAG	0	0.00	0	0.00	1	0.01	1	0.003	1	0.004	1	0.003	1	0.003
UTR-11	DelCCCCCGAC	0	0.00	0	0.00	0	0.00	1	0.003	0	0.00	1	0.003	1	0.003
UTR-13	DelCTCCTGAC	2	0.03^*	0	0.00	0	0.00	0	0.00	0	0.00^*	0	0.00	0	0.00^*
UTR-14	DelCTGCCGGC	1	0.02	3	0.03^*	0	0.00	0	0.00	3	0.01	0	0.00	0	0.00^*
UTR-17	InsTTCCTGAC	0	0.00	0	0.00	1	0.01	0	0.00	1	0.004	0	0.00	0	0.00
Others^a	DelCCGCCCGC	0	0.00	1	0.01	0	0.00	0	0.00	1	0.004	0	0.00	0	0.00
	DelCTCACCAC	0	0.00	1	0.01	0	0.00	0	0.00	1	0.004	0	0.00	0	0.00
	DelCTCCCCAC	0	0.00	0	0.00	1	0.01	0	0.00	1	0.004	0	0.00	0	0.00
	DelCTCCCCGC	0	0.00	0	0.00	1	0.01	0	0.00	1	0.004	0	0.00	0	0.00
	DelCCGACCGC	0	0.00	1	0.01	0	0.00	0	0.00	1	0.004	0	0.00	0	0.00
	InsCTCCCCAG	0	0.00	0	0.00	2	0.02	0	0.00	2	0.01	0	0.00	0	0.00
	InsCTGCCCAC	0	0.00	2	0.02	0	0.00	0	0.00	2	0.01	0	0.00	0	0.00
	InsCTGCCCGC	1	0.02	0	0.00	1	0.01	0	0.00	1	0.004	0	0.00	0	0.00

(b)

Haplotype	Comparison	OR (95% CI)	Comparison	OR (95% CI)	Comparison	OR (95% CI)
UTR-4	W versus H	0.354 (0.20–0.64)	CDM versus H	0.339 (0.18–0.65)	D versus H	0.406 (0.18–0.93)
	C versus H	0.207 (0.06–0.69)
UTR-7	D versus I	0.048 (0.003–0.88)	D versus M	0.039 (0.002–0.74)	D versus H	0.070 (0.004–1.17)
UTR-13	CDM versus I	0.050 (0.002–1.06)	I versus H	23.346 (1.08–491.92)
UTR-14	C versus H	22.759 (1.17–444.53)

I (indeterminate). C (cardiac). D (digestive). M (mixed). CDM (patients presenting clinically detected disease). W (whole group). H (healthy control). Del (deletion), Ins (insertion), OR, Odds Ratio, 95% CI, 95% Confidence Interval. ^*frequencies that show statistical differences. ^aGroup of haplotypes occurring at a frequency of ≤0.02.