Bromoenol Lactone, an Inhibitor of Calcium-Independent Phospholipase A2, Suppresses Carrageenan-Induced Prostaglandin Production and Hyperalgesia in Rat Hind Paw
Paw-withdrawal latencies to radiant heat. (a) The latencies were reduced by approximately 70% after carrageenan (Car) injection in vehicle-treated group. The reduction was statistically significant throughout the observation period of 6 h (, , multiple t-tests with Bonferroni correction, 6 comparisons among 7 groups; time point 0 versus time points 1–6). Treatment with BEL but not with AACOCF3 prolonged the latencies at 1 h, 2 h, and 3 h after injection. At these time points, the effect of BEL was statistically significant (, 0.014, and 0.015, resp., multiple t-tests with Bonferroni correction, 2 comparisons among 3 groups; vehicle versus BEL and vehicle versus AACOCF3 in each time point). Asterisks indicate the statistical significance of the difference between vehicle + carrageenan group and BEL + carrageenan group. (b) Saline (Sal) injection had little effect on paw-withdrawal latencies. PLA2 inhibitors did not influence the latencies in saline-injected groups.
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