Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm

<div>Model of inflammation as a driver of expansion of the<i> JAK2V617F</i> clone in MPN.<i> JAK2V617F</i>-mutated hematopoietic stem cells (HSC) are resistant to inflammation giving them a selective advantage in environments with high inflammation.</div>

Mediators of Inflammation

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Figure 2

Figure 2: Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm 