Mediators of Inflammation / 2015 / Article / Fig 2

Review Article

Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm

Figure 2

Model of inflammation as a driver of expansion of the JAK2V617F clone in MPN. JAK2V617F-mutated hematopoietic stem cells (HSC) are resistant to inflammation giving them a selective advantage in environments with high inflammation.

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