Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy

Table 3

Culture-based detection of pathogens in UAW and LAW before and after IV-AB therapy.

	Age/gender	Site	Before therapy	After therapy
Pat. 1	35 yrs/m; No chronic colonization evaluable due to lack of data	UAW	P. aeruginosa (mucoid); S. aureus	P. aeruginosa (mucoid); P. aeruginosa
		LAW	P. aeruginosa (mucoid); S. aureus; Enterococcus aureus	P. aeruginosa (mucoid); Yeast
Pat. 2	32 yrs/f	UAW	MRSA	n.m.
		LAW	MRSA; Aspergillus flavus	Culture negative
Pat. 3	30 yrs/f; Permanent P.a.^+ UAW/LAW; Intermittent S.a.^+ UAW/LAW (MRSA)	UAW	P. aeruginosa (mucoid); MRSA; Klebsiella oxytoca	P. aeruginosa (mucoid); P. aeruginosa
		LAW	P. aeruginosa (mucoid); P. aeruginosa; MRSA; Enterococcus spp.	P. aeruginosa (mucoid); P. aeruginosa; Yeast
Pat. 4	30 yrs/m^*	UAW	E. coli	P. aeruginosa (mucoid); P. aeruginosa
		LAW	P. aeruginosa (mucoid); P. aeruginosa; S. aureus; E. coli	P. aeruginosa (mucoid); P. aeruginosa; Yeast
Pat. 5	27 yrs/m; Permanent P.a.^+ UAW/LAW; Permanent S.a.^+ LAW; Intermittent S.a.^+ UAW	UAW	P. aeruginosa (mucoid); S. aureus; Serratiamarcescens	Comamonas testosteroni/P. alcaligenes
		LAW	P. aeruginosa (mucoid); S. aureus	P. aeruginosa (mucoid); Yeast
Pat. 6	25 yrs/f; Intermittent P.a.^+ LAW	UAW	Culture negative	Culture negative
		LAW	P. aeruginosa (mucoid); P. aeruginosa; E. coli	P. aeruginosa; E. coli
Pat. 7	23 yrs/f; Intermittent P.a.^+ UAW/LAW	UAW	Culture negative	P. aeruginosa
		LAW	Culture negative	Culture negative
Pat. 8	23 yrs/f; Permanent S.a.^+ UAW/LAW	UAW	Culture negative	Culture negative
		LAW	Yeast	Yeast
Pat. 9	18 yrs/m^*	UAW	n.m.	Culture negative
		LAW	S. aureus	Culture negative
Pat. 10	35 yrs/f; Permanent P.a.^+ LAW; Intermittent P.a.^+ UAW	UAW	P. aeruginosa	n.m.
		LAW	P. aeruginosa (mucoid); P. aeruginosa; Yeast	n.m.
Pat. 11	31 yrs/f; Intermittent S.a.^* LAW?	UAW	E. coli; Proteus mirabilis	E. coli
		LAW	E. coli; Proteus mirabilis; Aspergillus fumigatus; Yeast	E. coli; Aspergillus fumigatus; P. fluorescens
Pat. 12	15 yrs/f; Intermittent P.a.^+ UAW/LAW; Permanent S.a.^+ UAW/LAW	UAW; LAW	P. aeruginosa; P. aeruginosa	Culture negative; Culture negative
Pat. 13	25 yrs/f; Permanent P.a.^+ UAW/LAW	UAW	P. aeruginosa (mucoid); Enterococcus faecalis	Culture negative
		LAW	P. aeruginosa (mucoid); P. aeruginosa; Aspergillus fumigatus	Culture negative
Pat. 14	30 yrs/m; Permanent P.a.^+ UAW/LAW	UAW	E. coli; P. fluorescens	n.m.
		LAW	E. coli; P. fluorescens; S. viridans; Yeast	Aspergillus fumigatus; Klebsiella oxytoca; P. putida; Enterobacter cloacae; Yeast
Pat. 15	8 yrs/m; Intermittent P.a.^+ UAW; Permanent S.a.^+ UAW/LAW	UAW; LAW	Culture negative; Haemophilus parainfluenzae	Culture negative; Culture negative
Pat. 16	22 yrs/f^*
	Course 1	UAW	P. aeruginosa (mucoid); P. aeruginosa	P. aeruginosa (mucoid); P. aeruginosa
		LAW	P. aeruginosa (mucoid); P. aeruginosa; Aspergillus fumigatus	P. aeruginosa (mucoid); P. aeruginosa
	Course 2	UAW	n.m.	P. aeruginosa (mucoid); P. aeruginosa
		LAW	n.m.	P. aeruginosa; Streptococcus pneumoniae
Pat. 17	24 yrs/m^*
	Course 1	UAW	P. aeruginosa (mucoid); P. aeruginosa	P. aeruginosa (mucoid); P. aeruginosa; Enterococci
		LAW	P. aeruginosa (mucoid); Yeast	Yeast
	Course 2	UAW	n.m.	n.m.
		LAW	n.m.	n.m.

f = female, m = male, and n.m. = not measured.
^*Chronic colonization status not evaluable due to lack of data.