Mediators of Inflammation / 2015 / Article / Tab 1 / Review Article
Interleukin-1 Family Cytokines in Liver Diseases Table 1 Pathophysiological roles of IL-1 family members. The cellular source, target cells, and major functions of IL-1 family cytokines are shown. Representative diseases involving each cytokine are also shown. The precise disease relevancy is described in the text.
Cytokine Cellular sources Targets Major functions Liver diseases Other diseases IL-1 Many cell types Many cell types Inflammation Sterile inflammation Sterile inflammation IL-1 Many cell types Many cell types Inflammation, Th17 induction Sterile inflammation NAFLD Sterile inflammation Autoinflammatory diseases IL-33 Many cell types ICL2, basophils, eosinophils, mast cells Wound healing Type 2 response Liver fibrosis Nematode-associated disease, allergic diseases, fibrosis IL-18 Many cell types NK cells, Th1 cells, mast cells, basophils Inflammation, Th1 response, allergic response Innate immunity-mediated liver injury Chronic dermatitis, intrinsic allergy IL-37 Unknown murine orthologue Many cell types Inhibition of innate and acquired immunity Unknown Protection of sepsis IL-36 Many cell types Skin Recruitment of neutrophils Unknown Psoriasis
COPD: chronic obstructive pulmonary disease; ICL2: group 2 innate lymphoid cells; NAFLD: nonalcoholic fatty liver disease.