IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1-Dependent Glycolytic Pathway in Th17 Cells

Figure 4

Blockade of IL-1 signaling in donor cells inhibits severity of acute graft-versus-host disease (GVHD). (a) Splenocytes (from C57BL/6 mice) that were cultured with or without IL-1 receptor antagonist (IL-1Ra) for 2 h were transplanted into recipient mice (BALB/c), and the clinical features of acute GVHD were then monitored ( per group). (b) Twelve days after the bone marrow transplant (BMT), histopathological analysis was performed on the skin and small intestine. . Data are representative of 2 independent experiments.

(a)

(b)