Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults

Figure 1

Hypoxia preconditioning exerts significant neuroprotection in neonatal hypoxia-ischemia brain injury. (a) The ratio of hemispheric brain weight reduction measured 7 days after hypoxia-ischemia injury was significantly reduced in the hypoxia preconditioning group (HP + HI), compared with the hypoxia-ischemia only (HI) group. (b) Nissl stained frozen sections showed extensive brain damage in the ipsilateral hemisphere 24 h after hypoxia-ischemia injury (HI, left panel), which was attenuated by hypoxia preconditioning (HP + HI, right panel).

(a)

(b)