Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults

Figure 6

Hypoxia preconditioning suppresses prolonged hypoxia-induced inflammation in the BV-2 microglial cell line. (a) Brief hypoxia exposure (0.5, 1, and 2 h) before prolonged hypoxia damage (4 h) significantly reduced the production of nitrite. compared with hypoxia control. (b) mRNA expression of tumor necrosis factor-alpha (TNF-α) was suppressed by brief hypoxia preconditioning. compared with normoxia control and compared with hypoxia control. (c) mRNA expression of interleukin-1 beta (IL-1β) was also suppressed by brief hypoxia preconditioning. compared with normoxia control and compared with hypoxia control. ((a), (b), (c)) The data represent the mean ± standard error of the mean (SEM), based on five independent experiments in each group.

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