Prostacyclin Synthase: Upregulation during Renal Development and in Glomerular Disease as well as Its Constitutive Expression in Cultured Human Mesangial Cells

Figure 4

Pattern of COX1- and COX2-dependent prostanoid formation of human mesangial cells. HMCs were incubated for 20 h with cytokines in the absence or presence of diclofenac (1 μM), dexamethasone (1 μM), or vehicle. Prostanoid formation was measured in the supernatant. Data represent means (pg/10⁶ cells) ± SEM . One-way analysis of variance Bonferroni’s multiple comparison test was performed for each product. versus control; and versus cytokines; ns: nonsignificant.