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Mediators of Inflammation
Volume 2015, Article ID 671417, 10 pages
http://dx.doi.org/10.1155/2015/671417
Review Article

Macrophages and Uveitis in Experimental Animal Models

1Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Valencia, Spain
2FISABIO, Oftalmología Médica, 46020 Valencia, Spain

Received 16 January 2015; Revised 14 March 2015; Accepted 31 March 2015

Academic Editor: Analía Trevani

Copyright © 2015 Salvador Mérida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in eye inflammation processes, including macrophage polarization in experimental autoimmune uveoretinitis and the major role of Toll-like receptor 4 in endotoxin-induced uveitis. This improved knowledge should guide advantageous iterative research to establish mechanisms and possible therapeutic targets for human uveitis resolution.