Inflammatory and Antioxidant Pattern Unbalance in “Clopidogrel-Resistant” Patients during Acute Coronary Syndrome
Table 4
Time-dependent changes of Hcy and chemotactic molecules levels.
Responders
Nonresponders
24 hours
1 week
1 month
24 hours
1 week
1 month
r-Hcypl, μmol/L
0.20 (0.15–0.25)
0.20 (0.14–0.20)
0.20 (0.15–0.30)
0.307
0.17 (0.10–0.19)
0.18 (0.12–0.22)
0.21 (0.12–4.48)
0.050
t-Hcypl, μmol/L
13.0 (8.6–15.2)
12.1 (10.9–14.6)
12.1 (10.4–15.7)
0.936
13.9 (9.8–16.6)
11.6 (9.4–13.2)
12.3 (9.9–36.2)
0.368
I-TAC, pg/mL
177 (162–228)
207 (88–292)
187 (89–268)
0.144
74 (0–170)
76 (0–202)
32 (0–224)
0.223
IP10, pg/mL
949 (726–2223)
986 (817–1317)
1060 (765–1550)
0.344
1532 (698–2118)
1135 (877–2764)
1122 (941–2751)
0.819
MCP-1, pg/mL
17.3 (14.8–31.8)
19.5 (11.0–24.5)
19.5 (15.5–31.1)
0.420
21.1 (15.0–31.3)
41.7 (20.1–50.3)
28.1 (15.4–31.8)
0.819
MIP-1, pg/mL
78.1 (58.2–108.4)
65.7 (50.1–108.7)
75.4 (45.5–94.0)
0.549
115.3 (96.3–131.3)
99.1 (84.8–120.9)
124.6 (72.2–140.8)
0.549
Data are expressed as median and interquartile range (25th–75th). pl: plasma; r: reduced; t: total; I-TAC: interferon-inducible T cell alpha chemoattractant; MCP-1: monocyte chemotactic protein-1; MIP-1: macrophage inflammatory protein-1; TNF: tumor necrosis factor; Th1/Th2: T helper type 1 or type 2 cells. : time-dependent changes (24 hours, 1 week, and 1 month) in groups assessed by nonparametric Friedman test.
