ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury

Figure 4

BAY11-7082 alleviated the burn-induced ALI. Rats were subjected to burn injury. BAY11-7082 was administered intraperitoneally immediately after burn injury in rats. At 24 h and 48 h after burn injury, lung tissue was collected. Histopathological changes (a) were assessed by H&E staining and the pulmonary histologic score (b) was counted. Total protein contents in BALF (c) were examined by BCA protein assay kit. The levels of MPO in lung homogenate (d) were tested by MPO kits. IL-1β (e) and IL-18 (f) mRNA expression in rat lungs were analyzed by real-time PCR. The values presented are mean ± SEM ( per group). .

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