Mediators of Inflammation

Mediators of Inflammation / 2015 / Article

Evaluation of Serum Amyloid A as a Marker of Persistent Inflammation in Patients with Rheumatoid Arthritis

  • Mehmet Agilli | Fevzi Nuri Aydin | ... | Yasemin Gulcan Kurt |
  •  Article ID 843152 |
  •  Published 28 Jan 2015
  • | View Article

Response to: Comment on “Serum Amyloid A as a Marker of Persistent Inflammation and an Indicator of Cardiovascular and Renal Involvement in Patients with Rheumatoid Arthritis”

  • Bożena Targońska-Stępniak | Maria Majdan |
  •  Article ID 749565 |
  •  Published 23 Feb 2015

Letter to the Editor | Open Access

Volume 2015 |Article ID 749565 | https://doi.org/10.1155/2015/749565

Bożena Targońska-Stępniak, Maria Majdan, "Response to: Comment on “Serum Amyloid A as a Marker of Persistent Inflammation and an Indicator of Cardiovascular and Renal Involvement in Patients with Rheumatoid Arthritis”", Mediators of Inflammation, vol. 2015, Article ID 749565, 1 page, 2015. https://doi.org/10.1155/2015/749565

Response to: Comment on “Serum Amyloid A as a Marker of Persistent Inflammation and an Indicator of Cardiovascular and Renal Involvement in Patients with Rheumatoid Arthritis”

Academic Editor: Eeva Moilanen
Received15 Jan 2015
Accepted15 Jan 2015
Published23 Feb 2015

We thank the authors for the detailed analysis of the paper “Serum Amyloid A as a Marker of Persistent Inflammation and an Indicator of Cardiovascular and Renal Involvement in Patients with Rheumatoid Arthritis.” We do appreciate your comments.

However, the roles of some factors influencing serum amyloid A (SAA) concentration, indicated by the authors, have been discussed in the paper—the role of treatment with glucocorticoids and disease modifying drugs (DMARDs), including biological DMARDs [1]. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) was not regular; they were taken by the patients on demand, during periods of joint pain exacerbation and in variable doses. That is why reliable analysis of NSAID influence on SAA level was not available. We did not analyze the treatment with statins.

Most of diseases mentioned in the “Letter to the Editor” potentially influencing SAA level did not occur in our patients. The study group consisted of patients with rheumatoid arthritis (RA) and they did not suffer from other types of arthritis (ankylosing spondylitis) or autoinflammatory diseases (familial Mediterranean fever, systemic lupus erythematosus, and vasculitis), inflammatory bowel diseases, acute pancreatitis, psoriasis, epilepsy, and major depression. Diabetes mellitus was found only in 6 patients (4.3%).

Dietary food supplements and antioxidants are not prescribed routinely by physicians and are used by patients themselves. It is also difficult to establish the actual alcohol use. We did not collect the detailed questionnaire of patients’ diet and habits; it was not a goal for our study.

However, smoking cigarettes is quite an important factor involved in the pathogenesis and activity of RA. In our study group current smoking was reported by 29 patients (20.7%) and 111 patients (79.3%) did not smoke cigarettes at the time of examination. We analyzed the data and found no correlation between the status of smoking and SAA serum concentration.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

References

  1. B. Targońska-Stępniak and M. Majdan, “Serum amyloid A as a marker of persistent inflammation and an indicator of cardiovascular and renal involvement in patients with rheumatoid arthritis,” Mediators of Inflammation, vol. 2014, Article ID 793628, 7 pages, 2014. View at: Publisher Site | Google Scholar

Copyright © 2015 Bożena Targońska-Stępniak and Maria Majdan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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