Mediators of Inflammation / 2015 / Article / Tab 1 / Review Article
Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications Table 1 Studies assessing regulatory T (Treg) cell number and function in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis.
Authors (year) Reference Treg cells FoxP3 assessment Treg suppressive activity PB SF SM PB SF Cao et al. (2003) [10 ] = to HD ↑versus RA PB N.A. No N.A. Present Cao et al. (2004) [11 ] ↓ versus HD ↑versus RA PB N.A. No N.A. Present Ehrenstein et al. (2004) [35 ] N.A. N.A. N.A. Yes Impaired N.A. van Amelsfort et al. (2004) [12 ] ↑ versus HD ↑ versus RA PB N.A. No Present ↑ versus RA PB Möttönen et al. (2005) [13 ] = to HD ↑ versus RA PB N.A. Yes N.A. Present Liu et al. (2005) [14 ] = to HD ↑ versus RA PB N.A. No Present Present Cao et al. (2006) [15 ] N.A. ↑ versus RA PB N.A. Yes N.A. Present Dombrecht et al. (2006) [27 ] = to HD N.A. N.A. No N.A. N.A. van Amelsfort et al. (2007) [28 ] N.A. N.A. N.A. No Present Present Behrens et al. (2007) [32 ] N.A. N.A. Present Yes N.A. N.A. Lin et al. (2007) [25 ] = to HD N.A. N.A. Yes N.A. N.A. Jiao et al. (2007) [16 ] ↓ versus HD ↑ versus RA PB N.A. Yes N.A. N.A. Han et al. (2008) [24 ] ↑ versus HD N.A. N.A. Yes Present N.A. Raghavan et al. (2009) [33 ] N.A. N.A. Present Yes N.A. Present Sempere-Ortells et al. (2009) [19 ] ↓ versus HD N.A. N.A. Yes N.A. N.A. Dejaco et al. (2010) [18 ] = to HD ↑ versus RA PB N.A. No N.A. N.A. Kawashiri et al. (2011) [20 ] ↓ versus HD N.A. N.A. No N.A. N.A. Lina et al. (2011) [23 ] ↓ versus HD N.A. N.A. Yes N.A. N.A. Niu et al. (2012) [21 ] ↓ versus HD N.A. N.A. Yes N.A. N.A.
Xq et al. (2012) [34 ] N.A. N.A. Present ↑ versus OA-SM N.A. N.A. Samson et al. (2012) [22 ] ↓ versus HD N.A. N.A. Yes Present N.A. Ji et al. (2013) [26 ] = to HD N.A. N.A. Yes N.A. N.A. Moradi et al. (2014) [17 ] = to OA ↑ versus RA PB Present Yes N.A. N.A. Guggino et al. (2015) [36 ] ↓ versus HD N.A. N.A. Yes N.A. N.A.
PB: peripheral blood; SF: synovial fluid; SM: synovial membrane; RA: rheumatoid arthritis; OA: osteoarthritis; HD: healthy donors; N.A.: not applicable.