Genetic and Environmental Influences on Retinopathy of Prematurity

<div>The pathophysiology of ROP is dynamic, influenced by genetic, environmental, and random factors. <svg height="6.20645pt" id="M49" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -6.00005 5.58009 6.20645" width="5.58009pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M396 374C396 399 365 451 262 451C173 451 84 405 84 327C84 295 107 257 157 243V241C91 226 24 184 24 119C24 41 92 -12 189 -12C272 -12 344 31 386 91L367 118C325 76 274 50 222 50C163 50 120 84 120 138C120 191 169 218 223 218C247 218 263 217 278 216L312 260L308 267H259C200 267 167 297 167 338S202 414 250 414C297 414 326 387 336 341C338 331 341 328 349 328C361 328 396 349 396 374Z" id="g50-247"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="420" vert-adv-y="420"></glyph.data></g></svg>, random error; <svg height="7.94193pt" id="M50" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.73553 4.62753 7.94193" width="4.62753pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M329 433H203L239 587L230 596L147 534L123 433H57L30 395L34 388H115L61 129C37 16 59 -12 85 -12C147 -12 222 58 260 98L241 125C212 95 160 62 144 62C132 62 127 71 138 126L192 386L305 394L329 433Z" id="g50-117"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="347" vert-adv-y="347"></glyph.data></g></svg>, ROP phenotype; <svg height="9.49473pt" id="M51" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -9.28833 6.97631 9.49473" width="6.97631pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M509 90L493 118C465 91 427 70 418 70S409 77 415 103L469 327C494 429 466 451 436 451C412 451 387 444 356 427C307 400 222 342 160 264H158L246 667C253 701 252 710 243 710C228 710 169 680 87 673L83 644H117C155 644 160 640 149 588L24 -4L32 -12C57 -4 86 4 108 9L143 187C198 275 324 386 375 386C394 386 399 367 385 311L331 87C315 22 322 -12 351 -12C387 -12 452 24 509 90Z" id="g50-105"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="527" vert-adv-y="527"></glyph.data></g></svg>, heritability; <svg height="6.20645pt" id="M52" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -6.00005 5.60619 6.20645" width="5.60619pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M398 365C398 411 356 451 297 451C250 451 198 430 151 397C65 336 24 230 24 139C24 14 97 -12 148 -12C198 -12 284 7 373 104L355 130C306 84 246 53 198 53C132 53 111 109 111 163V189C209 211 398 261 398 365ZM317 351C317 308 273 262 117 225C134 338 189 383 221 399C230 404 249 407 263 407C295 407 317 389 317 351Z" id="g50-102"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="422" vert-adv-y="422"></glyph.data></g></svg> = environmental factors.</div>

Mediators of Inflammation

Genetic and Environmental Influences on Retinopathy of Prematurity

Figure 1