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Mediators of Inflammation
Volume 2015 (2015), Article ID 764250, 7 pages
http://dx.doi.org/10.1155/2015/764250
Review Article

Serum Uric Acid Increases Risk of Cancer Incidence and Mortality: A Systematic Review and Meta-Analysis

1Department of Surgical Oncology, The Eighty-First Hospital of People’s Liberation Army, Nanjing 210002, China
2Liver Transplantation Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
3Department of Surgery Emergency, People’s Hospital of Rizhao, Rizhao 276800, China
4Center of Computer Network, People’s Hospital of Rizhao, Rizhao 276800, China
5Department of Cardiology, People’s Hospital of Rizhao, Rizhao 276800, China
6Department of Endocrinology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China
7Department of Rheumatism, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China

Received 8 October 2014; Accepted 1 December 2014

Academic Editor: Anshu Agrawal

Copyright © 2015 Shushan Yan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. K. Glantzounis, E. C. Tsimoyiannis, A. M. Kappas, and D. A. Galaris, “Uric acid and oxidative stress,” Current Pharmaceutical Design, vol. 11, no. 32, pp. 4145–4151, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. D. H. Kang and S. K. Ha, “Uric acid puzzle: dual role as anti-oxidantand pro-oxidant,” Electrolyte and Blood Pressure, vol. 12, no. 1, pp. 1–6, 2014. View at Publisher · View at Google Scholar
  3. L. A. Colangelo, S. M. Gapstur, P. H. Gann, A. R. Dyer, and K. Liu, “Colorectal cancer mortality and factors related to the insulin resistance syndrome,” Cancer Epidemiology Biomarkers and Prevention, vol. 11, no. 4, pp. 385–391, 2002. View at Google Scholar · View at Scopus
  4. L. J. Horsfall, I. Nazareth, and I. Petersen, “Serum uric acid and the risk of respiratory disease: a population-based cohort study,” Thorax, vol. 69, pp. 1021–1026, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Y. Kim, D. W. Lee, S. B. Lee, and I. S. Kwak, “The role of uric acid in kidney fibrosis: experimental evidences for the causal relationship,” BioMed Research International, vol. 2014, Article ID 638732, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Fang, X. Li, J. J. Luo, H. Wang, and X. F. Yang, “A double-edged sword: uric acid and neurological disorders,” Brain Disorders & Therapy, vol. 2, no. 2, p. 109, 2013. View at Google Scholar
  7. B. N. Ames, R. Cathcart, E. Schwiers, and P. Hochstein, “Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 78, no. 11, pp. 6858–6862, 1981. View at Publisher · View at Google Scholar · View at Scopus
  8. C.-F. Kuo, L.-C. See, K.-H. Yu, I.-J. Chou, M.-J. Chiou, and S.-F. Luo, “Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality,” Rheumatology, vol. 52, no. 1, pp. 127–134, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. A. M. Strasak, K. Rapp, W. Hilbe et al., “Serum uric acid and risk of cancer mortality in a large prospective male cohort,” Cancer Causes and Control, vol. 18, no. 9, pp. 1021–1029, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. M. Strasak, S. Lang, T. Kneib et al., “Use of penalized splines in extended Cox-type additive hazard regression to flexibly estimate the effect of time-varying serum uric acid on risk of cancer incidence: a prospective, population-based study in 78,850 men,” Annals of Epidemiology, vol. 19, no. 1, pp. 15–24, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. L. N. Kolonel, C. Yoshizawa, A. M. Y. Nomura, and G. N. Stemmermann, “Relationship of serum uric acid to cancer occurrence in a prospective male cohort,” Cancer Epidemiology Biomarkers and Prevention, vol. 3, no. 3, pp. 225–228, 1994. View at Google Scholar · View at Scopus
  12. R. A. Hiatt and B. H. Fireman, “Serum uric acid unrelated to cancer incidence in humans,” Cancer Research, vol. 48, no. 10, pp. 2916–2918, 1988. View at Google Scholar · View at Scopus
  13. N. Taghizadeh, J. M. Vonk, and H. M. Boezen, “Serum uric acid levels and cancer mortality risk among males in a large general population-based cohort study,” Cancer Causes & Control, vol. 25, no. 8, pp. 1075–1080, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. S. P. Juraschek, H. Tunstall-Pedoe, and M. Woodward, “Serum uric acid and the risk of mortality during 23 years follow-up in the Scottish heart health extended cohort study,” Atherosclerosis, vol. 233, no. 2, pp. 623–629, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. M. Strasak, K. Rapp, W. Hilbe et al., “The role of serum uric acid as an antioxidant protecting against cancer: prospective study in more than 28 000 older Austrian women,” Annals of Oncology, vol. 18, no. 11, pp. 1893–1897, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. S. H. Jee, S. Y. Lee, and M. T. Kim, “Serum uric acid and risk of death from cancer, cardiovascular disease or all causes in men,” European Journal of Cardiovascular Prevention and Rehabilitation, vol. 11, no. 3, pp. 185–191, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Tomita, S. Mizuno, H. Yamanaka et al., “Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers,” Journal of Epidemiology, vol. 10, no. 6, pp. 403–409, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. S. M. Gapstur, P. H. Gann, W. Lowe, K. Liu, L. Colangelo, and A. Dyer, “Abnormal glucose metabolism and pancreatic cancer mortality,” The Journal of the American Medical Association, vol. 283, no. 19, pp. 2552–2558, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Mazza, E. Casiglia, R. Scarpa et al., “Predictors of cancer mortality in elderly subjects,” European Journal of Epidemiology, vol. 15, no. 5, pp. 421–427, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. W. G. Cochran, “The comparison of percentages in matched samples,” Biometrika, vol. 37, no. 3-4, pp. 256–266, 1950. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  21. J. P. T. Higgins, S. G. Thompson, J. J. Deeks, and D. G. Altman, “Measuring inconsistency in meta-analyses,” British Medical Journal, vol. 327, no. 7414, pp. 557–560, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Mantel and W. Haenszel, “Statistical aspects of the analysis of data from retrospective studies of disease,” Journal of the National Cancer Institute, vol. 22, no. 4, pp. 719–748, 1959. View at Google Scholar
  23. R. DerSimonian and N. Laird, “Meta-analysis in clinical trials,” Controlled Clinical Trials, vol. 7, no. 3, pp. 177–188, 1986. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Egger, G. D. Smith, M. Schneider, and C. Minder, “Bias in meta-analysis detected by a simple, graphical test,” British Medical Journal, vol. 315, no. 7109, pp. 629–634, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. A. E. Stuck, L. Z. Rubenstein, and D. Wieland, “Bias in meta-analysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity,” British Medical Journal, vol. 316, no. 7129, pp. 469–461, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Baeksgaard and J. B. Sørensen, “Acute tumor lysis syndrome in solid tumors—a case report and review of the literature,” Cancer Chemotherapy and Pharmacology, vol. 51, no. 3, pp. 187–192, 2003. View at Google Scholar · View at Scopus
  27. A. Sevanian, K. J. A. Davies, and P. Hochstein, “Serum urate as an antioxidant for ascorbic acid,” The American Journal of Clinical Nutrition, vol. 54, supplement 6, pp. 1129S–1134S, 1991. View at Google Scholar · View at Scopus
  28. M. A. Fini, A. Elias, R. J. Johnson, and R. M. Wright, “Contribution of uric acid to cancer risk, recurrence, and mortality,” Clinical and Translational Medicine, vol. 1, no. 1, p. 16, 2012. View at Google Scholar