Protein Phosphatase 2A Mediates Oxidative Stress Induced Apoptosis in Osteoblasts

Figure 1

Oxidative stress induces cell apoptosis in osteoblasts. (a) MTT assay results indicate that osteoblastic viability (%) was downregulated by 4-HNE treatment (10 or 50 μM for 0.5 to 2 h). ((b)-(c)) Hoechst staining and quantifications confirmed that 4-HNE treatment may induce dramatic osteoblastic apoptosis. Results are averages of three independent experiments. Data represent mean ± SEM. , , and .

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