Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans

Figure 1

Protocol used in experimental groups. Patients were pretreated without or with captopril for 1 hour (Cap1hr, 12.5 mg, oral administration) or 3 days (Cap3d, 12.5 mg, 3 times per day, oral administration) before surgery. After induction, all patients received continuous infusions of fentanyl at 0.6 gkg⁻¹ of body weightmin⁻¹ and pancuronium bromide at 15 gkg⁻¹ of body weightmin⁻¹ during surgery. The anaesthesia protocol in various groups is as follows: anaesthesia was maintained either with fentanyl and midazolam (group control, Cap1hr, and Cap3d) or with isoflurane 1.1 MAC (minimum alveolar anesthetic concentration) end tidal before surgery (group Cap1hr+Iso or Cap3d+Iso).