Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans

<div>Isoflurane (Iso) and captopril (Cap) improved postischemic myocardial function recovery in rabbits. (a) Heart rate, (b) mean arterial pressure (MAP), and (c) rate pressure product (RPP) at baseline and during ischemia and reperfusion. Sham: sham operated control; I/R: rabbits subjected to myocardial ischemia reperfusion (MI/R); Cap: rabbits treated with captopril (25 mg/kg given intravenously 24 h) prior to inducing MI/R; Iso: rabbits received isoflurane preconditioning (15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R); Iso+Cap: rabbits received captopril in combination with Iso. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans 

Figure 4 | Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans 