Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans

<div>Isoflurane (Iso) and captopril (Cap) ameliorated postischemic myocardial oxidative stress in rabbits. (a) Cardiac malondialdehyde (MDA) content, (b) plasma superoxide dismutases (SOD) levels. Sham: sham operated control; I/R: rabbits subjected to myocardial ischemia reperfusion (MI/R); Cap: rabbits treated with captopril (25 mg/kg given intravenously 24 h) prior to inducing MI/R; Iso: rabbits received isoflurane preconditioning (15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R); Iso+Cap: rabbits received captopril in combination with Iso. 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Mediators of Inflammation

fig6

Figure 6

Figure 6: Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans 

Figure 6 | Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans 