The Effect of Therapeutic Blockades of Dust Particles-Induced Ca²⁺ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells

Figure 4

PM₁₀-induced Ca²⁺ signal is attenuated by blocking the oxidative pathway. PM₁₀ (50 μg/mL) induced Ca²⁺ signaling in the presence of antioxidative compounds, (a) 1 mM DTT, (b) 5 mM NAC, and (c) 10 μM DPI, and (d) in the presence of 10 μM 3-AB, PARP-1 inhibitor. (e) Top bars on trace panels indicate the type of extracellular solutions applied to the cells. Data are represented as mean ± SE. values were considered significant. All traces are the reading from an experimental average. The dotted line shows the baseline at ratio 1.

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