Research Article
Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis
Figure 6
Blockade of CysLTR1 reduces the fungal loads recovered from P. brasiliensis infected macrophages. MTL (10−8, 10−6, and 10−4 M) treated IFN-γ primed (20 ng/mL) and unprimed peritoneal macrophages from B10.A, and A/J mice were infected with P. brasiliensis in a macrophage-yeast cells rate of 50 : 1. After 48 h of cocultivation, the monolayers were lysed and assayed for the presence of viable yeast cells by a CFU assay. Data are means ± SEM of results from quintuplicate samples from three independent experiments. .