Mediators of Inflammation / 2015 / Article / Fig 1

Clinical Study

Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study

Figure 1

Proposed relationship between neurogenic inflammatory and endogenous opioid analgesic mechanisms. SP: substance P, CGRP: calcitonin gene-related peptide, β-End: β-endorphin, Met-Enk: methionine-enkephalin, NK1-R: neurokinin 1 receptor, CGRP1/2-R: calcitonin gene-related peptide receptors 1 and 2, MOR: μ-opioid receptor, DOR: δ-opioid receptor, OEA: opioid endogenous analgesia, AI: asymptomatic inflammation, and PAN: primary afferent neuron.