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Mediators of Inflammation
Volume 2015, Article ID 904876, 8 pages
Research Article

25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression

1Nephrology Hospital “Dr. Carol Davila”, 4 Calea Grivitei, 010731 Bucharest, Romania
2SKINMED Clinic, 8 Splaiul Unirii, 040102 Bucharest, Romania
3Immunology Department, Victor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania
4Faculty of Biology, University of Bucharest, 91-95 Splaiul Independenţei, 76201 Bucharest, Romania
5Department in Dermatology, Infectious and Tropical Diseases “Dr. Victor Babeş” Clinical Hospital-Research, 281 Soseaua Mihai Bravu, 030303 Bucharest, Romania

Received 10 April 2015; Revised 5 June 2015; Accepted 10 June 2015

Academic Editor: Madhav Bhatia

Copyright © 2015 Corina-Daniela Ene et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research. Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL-8, and metabolic ones, such as vitamin D. These candidate biomarkers are intended to aid classical biomarkers, such as LDH, in the prognosis of cutaneous melanoma. Methods. Serum vitamin D and IL-8 were quantified in melanoma patients and in matching healthy controls. Results. Median serum vitamin D concentrations were significantly lower () in melanoma patients as compared to healthy control subjects, while around 65% of the investigated patients have proven a severe circulatory deficiency of this vitamin. IL-8 was found increased () in melanoma patients as compared to controls. Conclusion. Upregulation of proangiogenic factors associated with vitamin D deficiency can prove to be potent future biomarkers candidates, enhancing the predictive power of classical LDH.