25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression

Table 1

Inclusion and exclusion criteria for patients (a) and healthy subjects (b).

(a) Patients

Inclusion criteria	Age	18–45 years
	Sun exposure	UV index 5
	Nutrition, body mass index	Normal, 18.5–24.9
	Stage	Clark II, Clark III, Clark IV, and Clark V
Exclusion criteria	Age	>18 years; <45 years
	Pregnancy	Yes
	Condition present	Drug and/or alcoholic addiction
	Treatment present	Systemic treatment with hormones, antidepressants, antioxidants, and immunomodulators
	Other pathologies	Neurological, physiatrical, digestive, endocrinological, and cardiovascular diseases, liver-, renal-, and lung-related pathologies, metabolic disease, autoimmune, infections, inflammations, and other neoplastic diseases

(b) Healthy subjects

Inclusion criteria	Age	18–45 years
	Sun exposure	UV index 5
	Nutrition, body mass index	Normal, 18.5–24.9
	Calcemia, calciuria, phosphatemia, alkaline phosphatase, parathormone, and C reactive protein.	Normal values
Exclusion criteria	Age	>18 years; <45 years
	Pregnancy	Yes
	Condition present	Drug and/or alcoholic addiction
	Treatment present	Systemic treatment with hormones, antidepressants, antioxidants, and immunomodulators
	Other pathologies	Neurological, physiatrical, digestive, endocrinological, and cardiovascular diseases, liver-, renal-, and lung-related pathologies, metabolic disease, autoimmune, infections, inflammations, and other neoplastic diseases