Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury

Figure 1

Typical histological images of DILI. (a) Hepatocellular type. Histological examination showed centrilobular hepatic necrosis with punched out lesions. The inflammatory changes were relatively mild in the portal areas, compared with those in the liver parenchyma. (b) mixed type. There is dropout of liver cells in the perivenular zone and bridges of necrosis (“central to portal”). Note periportal mild to moderate inflammatory response. There is dropout of liver cells in the perivenular zone. Additionally cholestasis is observed. (c) Cholestatic type. Ballooning degeneration of liver cells and marked cholestasis (needle biopsy, H&E). C: central vein, P: portal vein, and black arrows: bile thrombus.

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