Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury

Box 1

Pathological features suggestive of DILI.

(1) The inflammatory changes in the portal areas are relatively mild compared with those in the liver parenchyma

(2) Demarcated perivenular (acinar zone 3) necrosis

(3) Confluent necrosis with little inflammation

(4) Minimal hepatitis with canalicular cholestasis

(5) Fat deposits in hepatocytes (≥30%)

(6) Abundant neutrophil infiltration

(7) Abundant eosinophil infiltration

(8) Presence of epithelioid-cell granulomas

(9) Biliary damage and inflammation

(10) Severe cholestasis