Modulation of Cytokines Production by Indomethacin Acute Dose during the Evolution of Ehrlich Ascites Tumor in Mice

Figure 1

Study setting and time period. To assess the involvement of prostaglandin in cytokines profile during growth of EAT, mice were inoculated with 1000 tumor cells intraperitoneally (i.p.) and received indomethacin at a dose of 1 mg/kg, once a day, via i.p. The first dose of indomethacin was administered 24 hours prior to tumor implantation. After 1, 3, 6, 10, and 13 days the animals were euthanized and evaluated for cytokine profile.