IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations

Figure 4

(a) Effect of IL-4 injection 2 hours after injection of i.c.v. IL-1β on NE concentration. Mean (±SEM) concentrations (picogram per gram) of NE within the mPFC, hippocampus, and hypothalamus among rats. Each value represents the mean ± SEM. compared to the CSF and , compared to the IL-1β treated group. Control, ; IL-1β, ; IL-4 100 ng, ; IL-4 200 ng, . (b) Effect of IL-4 injection 2 hours after injection of i.c.v. IL-1β on NET and TH mRNA levels in the brain. Values are means ± SEM. Relative % GAPDH of NET and TH mRNA levels within the mPFC and hippocampus among rats. Each value represents the mean ± SEM. compared to the CSF and , compared to the IL-1β treated group. Control, ; IL-1β, ; IL-4 100 ng, ; IL-4 200 ng, .

(a)

(b)