Bleomycin-Treated Chimeric Thy1-Deficient Mice with Thy1-Deficient Myofibroblasts and Thy-Positive Lymphocytes Resolve Inflammation without Affecting the Fibrotic Response

Table 3

Pathways involved in myofibroblast proliferation, differentiation, and interaction with the ECM and immune system that are affected by Thy1.

Category	Pathway	Gene name	Fold
Proliferation	Cell cycle	Anaphase promoting complex subunit 2	−1.19
		Cyclin D2	−1.02
		CDC23 (cell division cycle 23 yeast homology)	−1.13
		Transformed mouse 3T3 cell double minute 2	−1.22
	MAPK signaling pathway	RIKEN cDNA 1500003O03 gene	−1.03
		Thymoma viral proto-oncogene 2	−1.12
		Activating transcription factor 4	−1.1
		Filamin C, gamma (actin binding protein 280)	−1.05
		Protein phosphatase 1B, magnesium dependent, β isoform	−1.06
		v-raf-leukemia viral oncogene 1	−1.07
		Serine/theonine kinase 3 (Ste20, yeast homolog)	−1.2
		Fibroblast growth factor receptor 1	−1.13
	Insulin signaling pathway	RIKEN cDNA 4932417H02 gene	−1.22
		Thymoma viral proto-oncogene 2	−1.12
		Brain glycogen phosphorylase	−1.37
		v-raf-leukemia viral oncogene 1	−1.07
		Sorbin and SH3 domain containing 1	−1.46
	TGFβ signaling pathway	Activin receptor IIA	−1.16
		Protein phosphatase 2	−1.19
		Thrombospondin 1	−1
	Receptors	Angiotensin receptor like 1	−1.85
ECM production and interaction	Focal adhesion	Thymoma viral proto-oncogene 2	−1.12
		Caveolin, caveolae protein 1	−1.13
		Cyclin D2	−1.02
		Collagen, type I, alpha 1	−1.02
		Collagen, type IV, alpha 1	−1.12
		Filamin C, gamma (actin bineing protein 280)	−1.05
		Integrin beta 1 (fibronectin receptor beta)	−1.04
		Laminin, alpha 2	−1.22
		v-raf-leukemia viral oncogene 1	−1.07
		Thrombonspondin 1	−1.19
		Talin 1	−1.17
		vav 1 oncogene	−1.59
		Vinculin	−1.3
	ECM receptor interaction	Collagen, type I, alpha 1	−1.02
		Collagen, type VI, alpha 1	−1.12
		Dystroglycan 1	−1.33
		Integrin beta 1 (fibronectin receptor beta)	−1.04
		Laminn, alpha 2	−1.22
Myofibroblast differentiation	Regulation of actin cytoskeleton	Actin, alpha 2, smooth muscle, aorta	−1.54
		Cofilin 1, non-muscle	−1.35
		Fibroblast growth factor receptor 1	−1.13
		Guanine nucleotide binding protein, alpha 13	−1.2
		Integrin beta 1 (fibronectin receptor beta)	−1.04
		v-raf-leukemia viral oncogene 1	−1.07
		vav 1 oncogene	−1.59
		Vinculin	−1.3
	Differentiation	MyoD1	−1.83
		Pax 7	−1.89
Inflammation and immunological function	Hematopoietic cell lineage	CD4 antigen	1.280914
		CD8 antigen, alpha chain	1.74495
	Antigen processing and presentation	Interferon alpha 13	1.57917
	Cytokine-cytokine receptor interaction	Small chemokine (C-C motif) ligand 11	1.913514
		Chemokine (C-C motif) ligand 17	1.571759
		Chemokine (C-X3-C motif) ligand 1	1.0517
		Interferon alpha 13	1.57917
		Nerve GFR (TNFR superfamily member 16)	1.451481
		Nos2	2.31
		Interleukin-1 receptor	−1
		FasL	1.71
		Interleukin-17 receptor	−1.2
		Cytokine receptor like	−1.17

change is shown on a log₂ scale.