Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy

Figure 2

Characterization of Profile I kinetics of modulation of cytokines/chemokines in the conjunctival sac fluid of patients undergoing PRK treatment. The local levels of cytokines/chemokines were measured in conjunctival sac fluid samples collected from patients before and at the indicated time points after PRK. In (a), modulation of EGF, G-CSF, and IL-1RA is shown as representative of Profile I. Horizontal bars are median, upper and lower edges of box are 75th and 25th percentiles, and lines extending from box are 10th and 90th percentiles. Asterisks, compared to the values before PRK. In (b), the identified panel of cytokines/chemokines sharing Profile I kinetics of modulation was assessed for network analysis. The two most highly scored networks are shown. The links between the different proteins generated by IPA (ingenuity pathway analysis) are graphically illustrated and the key for the nodes and the lines are reported on the legend.

(a)

(b)